Dr. Jonathan Fletcher is a lab-based medical and pediatric oncologist and geneticist at Harvard Medical School, Brigham and Women’s Hospital, and Dana-Farber Cancer Institute. His lab focus is translational GIST and sarcoma research, where the main priority is to identify and validate novel therapeutic strategies. His research program has discovered oncogenic mechanisms in GIST and many sarcoma subtypes. By developing novel genomic and phospho-protein screens, his group identified the first FGFR1 and PDGFRA oncoproteins and the first ALK oncoproteins in solid tumors. They have advanced new models and biologic insights for GIST, leiomyosarcoma, MPNST, liposarcoma and endometrial stromal sarcoma, among others. His group performed preclinical validations and correlative science supporting the FDA-approved drug applications for GIST, and he coordinates international research consortia devoted to maximizing therapeutic response in GIST and leiomyosarcoma.
Dr. Fletcher’s clinical activities are in cancer diagnostics, with a focus on molecular cytogenetics. Fletcher was appointed Chief Scientific Officer in July, 2021.