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SARC Clinical Trials

Every day, our community of researchers, investigators, scientists, sarcoma centers, and biotech and pharmaceutical companies are working together in the development and support of clinical trials (studies). A list of SARC trials is provided here with a brief description and patient accrual status. Additionally, the National Institutes of Health provides an online registry and results database of clinical studies conducted around the world at ClinicalTrials.gov.

Patient participating in sarcoma trial

Active SARC Trials

SU2C - SARC032 - SPORE05

A Phase II Randomized Controlled Trial of Neoadjuvant Pembrolizumab With Radiotherapy and Adjuvant Pembrolizumab

Type of Sarcoma: Soft Tissue Sarcoma of the Extremity

Drug: Pembrolizumab

Accrual Status: Recruiting

Overall Study Principal Investigator:

David Kirsch, MD, PhD
Professor, Radiation Oncology / Professor of Pharmacology and Cell Biology
Duke University

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SARC033 - SPORE06

Phase 2 Study of Trametinib in Patients With Unresectable or Metastatic Epithelioid Hemangioendothelioma

Type of Sarcoma: Epithelioid Hemangioendothelioma

Drug: Trametnib

Accrual Status: Recruiting

Overall Study Principal Investigator:

Scott Schuetze, MD, PhD
Division of Hematology/Oncology
University of Michigan Comprehensive Cancer Center EDDOP

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SARC031

A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors

Type of Sarcoma: Unresectable or Metastatic NF1 Associated or Sporadic Malignant Peripheral Nerve Sheath Tumors (MPNST)

Drug: Selumetinib in Combination with Sirolimus

Accrual Status: Not Yet Recruiting

Overall Study Principal Investigator:

AeRang Kim, MD, PhD
Pediatric Oncologist
Children’s National Medical Center

Brigitte Widemann, MD
Senior Investigator, Pediatric Oncology Branch
National Cancer Institute

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SARC028

A phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients with Advanced Sarcomas

Type of Sarcoma: Undifferentiated Pleomorphic Sarcoma and Poorly Differentiated/Dedifferentiated Liposarcoma

Drug: Pembrolizumab

Accrual Status: Not Recruiting

Overall Study Principal Investigator:

Hussein Tawbi, MD
Associate Professor of Medicine
The University of Texas MD Anderson Cancer Center

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SARC024

A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes

Type of Sarcoma: Refractory Liposarcoma, Osteogenic Sarcoma, Ewing/Ewing-like Sarcomas and Rhabdomyosarcoma

Drug: Regorafenib and placebo (for Liposarcoma and Osteogenic Sarcoma only)

Accrual Status: Recruiting

Overall Study Principal Investigator:

Robert Maki, MD, PhD
Professor Pediatrics, Hematology & Oncology
Hofstra-Northwell School of Medicine

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ESP1 / SARC025 - SPORE03

ESP1/SARC025 Global Collaboration: A Phase I Study of a Combination of the PARP Inhibitor, Niraparib and Temozolomide or Irinotecan in Patients With Previously Treated, Incurable Ewing Sarcoma

Type of Sarcoma: Ewing Sarcoma

Drug: Niraparib and Temozolomide or Irinotecan

Accrual Status: Not Recruiting

Overall Study Principal Investigator:

Sandra Strauss, MD, PhD
Senior Lecturer and Consultant Medical Oncologist
University College London, Cancer Institute

Rashmi Chugh, MD
Assistant Professor
University of Michigan

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Closed SARC Trials

SARC023

A Phase I/II Trial of Ganetespib in Combination With the mTOR Inhibitor Sirolimus for Patients With Recurrent or Refractory Sarcomas Including Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors

Type of Sarcoma: Phase I all unresectable soft tissue or bone sarcomas and Phase II unresectable malignant peripheral nerve sheath tumor (MPNST)

Drug: Ganetespib and Sirolimus

Accrual Status: Completed

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SARC022

A Phase 2 Study of Linsitinib (OSI-906) in Pediatric and Adult Wild Type Gastrointestinal Stromal Tumors

Type of Sarcoma: Gastrointestinal stromal tumors

Drug: OSI-906

Accrual Status: Completed

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SARC021

A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma

Type of Sarcoma: Locally advanced or metastatic soft tissue sarcoma

Drug: TH-302 combined with doxorubicin vs. doxorubicin alone

Accrual Status: Completed

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SARC020

Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma

Type of Sarcoma: Advanced or Metastatic Untreated Soft Tissue Sarcoma

Drug: Trabectedin Infused to Doxorubicin

Accrual Status: Terminated

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SARC019

Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients

Type of Sarcoma: Metastatic GIST

Drug: Imatinib

Accrual Status: Terminated

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SARC018 - SPORE01

SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma

Type of Sarcoma: Metastatic Leiomyosarcoma

Drug: Mocetinostat & Gemcitabine

Accrual Status: Completed

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SARC016

Phase 2 Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors

Type of Sarcoma: Malignant Peripheral Nerve Sheath Tumor (MPNST) either Sporadic or NF1 Associated

Drug: Bevacizumab and Everolimus

Accrual Status: Completed

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SARC012

A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung

Type of Sarcoma: Osteosarcoma

Drug: Saracatinib and Placebo

Accrual Status: Completed

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SARC011

A Study of R1507 in Participants With Recurrent or Refractory Sarcoma

Type of Sarcoma: Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma

Drug: R1507

Accrual Status: Completed

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SARC009

Trial of Dasatinib in Advanced Sarcomas

Type of Sarcoma: Leiomyosarcoma, liposarcoma, MFH/pleomorphic undifferentiated sarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor, osteosarcoma (skeletal or extraosseous), chondrosarcoma, ewing’s, alveolar soft part sarcoma, chordoma, epithelioid sarcoma, giant cell tumor of bone, hemangiopericytoma/solitary fibrous tumor, gastrointestinal stromal tumors (GIST)

Drug: Dasatinib

Accrual Status: Completed

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SARC007

A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas

Type of Sarcoma: Chondrosarcoma, extra-skeletal myxoid chondrosarcoma or alveolar soft part sarcoma

Drug: Perifosine

Accrual Status: Completed

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SARC006

Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors

Type of Sarcoma: Malignant peripheral nerve sheath tumors sporadic or NF1 associated

Drug: Adriamycin/ifosfamide and Adriamycin/etoposide

Accrual Status: Completed

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SARC005

Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcoma

Type of Sarcoma: Uterine Leiomyosarcoma

Drug: Gemcitabine and Docetaxel

Accrual Status: Completed

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SARC004

Neoadjuvant Imatinib in Dermatofibrosarcoma Protuberans

Type of Sarcoma: Dermatofirbrosarcoma Protuberans

Drug: Gleevec (Imatinib Mesylate)

Accrual Status: Completed

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SARC003

Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma

Type of Sarcoma: Recurrent Ewing’s Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma

Drug: Gemcitabine and Docetaxel

Accrual Status: Completed

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