ESP1 / SARC025
ESP1/SARC025 Global Collaboration: A Phase I Study of a Combination of the PARP Inhibitor, Niraparib and Temozolomide or Irinotecan in Patients With Previously Treated, Incurable Ewing Sarcoma
Type of Sarcoma: Ewing Sarcoma
Drug: Niraparib, Temozolomide and Irinotecan
Accrual Status: Not Recruiting
SARC018 - SPORE01
SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma
Type of Sarcoma: Metastatic Leiomyosarcoma
Drug: Mocetinostat & Gemcitabine
Accrual Status: Completed
SARC019
Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients
Type of Sarcoma: Metastatic GIST
Drug: Imatinib
Accrual Status: Terminated
SARC022
A Phase 2 Study of Linsitinib (OSI-906) in Pediatric and Adult Wild Type Gastrointestinal Stromal Tumors
Type of Sarcoma: Gastrointestinal stromal tumors
Drug: OSI-906
Accrual Status: Completed
SARC021
A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Type of Sarcoma: Locally advanced or metastatic soft tissue sarcoma
Drug: TH-302 combined with doxorubicin vs. doxorubicin alone
Accrual Status: Completed
SARC020
Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma
Type of Sarcoma: Advanced or Metastatic Untreated Soft Tissue Sarcoma
Drug: Trabectedin Infused to Doxorubicin
Accrual Status: Terminated
SARC011
A Study of R1507 in Participants With Recurrent or Refractory Sarcoma
Type of Sarcoma: Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma
Drug: R1507
Accrual Status: Completed
SARC009
Trial of Dasatinib in Advanced Sarcomas
Type of Sarcoma: Leiomyosarcoma, liposarcoma, MFH/pleomorphic undifferentiated sarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor, osteosarcoma (skeletal or extraosseous), chondrosarcoma, ewing’s, alveolar soft part sarcoma, chordoma, epithelioid sarcoma, giant cell tumor of bone, hemangiopericytoma/solitary fibrous tumor, gastrointestinal stromal tumors (GIST)
Drug: Dasatinib
Accrual Status: Completed
SARC007
A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas
Type of Sarcoma: Chondrosarcoma, extra-skeletal myxoid chondrosarcoma or alveolar soft part sarcoma
Drug: Perifosine
Accrual Status: Completed
SARC006
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Malignant peripheral nerve sheath tumors sporadic or NF1 associated
Drug: Adriamycin/ifosfamide and Adriamycin/etoposide
Accrual Status: Completed
SARC005
Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcoma
Type of Sarcoma: Uterine Leiomyosarcoma
Drug: Gemcitabine and Docetaxel
Accrual Status: Completed
SARC004
Neoadjuvant Imatinib in Dermatofibrosarcoma Protuberans
Type of Sarcoma: Dermatofirbrosarcoma Protuberans
Drug: Gleevec (Imatinib Mesylate)
Accrual Status: Completed
SARC003
Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma
Type of Sarcoma: Recurrent Ewing’s Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma
Drug: Gemcitabine and Docetaxel
Accrual Status: Completed
SARC002
Comparison of Gemcitabine v. Gemcitabine Plus Docetaxel in Unresectable Soft Tissue Sarcoma
Type of Sarcoma: Unresectable soft tissue sarcoma
Drug: Gemcitabine and Docetaxel
Accrual Status: Completed
SARC001
Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma
Type of Sarcoma: Ewing's Family (including PNET), OsteosarcomaSynovial Sarcoma, Leiomyosarcoma, Rhabdomyosarcoma (including alveolar, embryonal and pleomorphic), Liposarcoma (all variants), Malignant Fibrous Histiocytoma, Peripheral Nerve Sheath (including MPNST, neurofibrosarcoma, schwannoma), Fibrosarcoma, Angiosarcoma (all variants), Desmoid Tumor, GI Stromal (c-kit negative only)
Drug: Imatinib Mesylate (Gleevec)
Accrual Status: Completed
SARC023
A Phase I/II Trial of Ganetespib in Combination With the mTOR Inhibitor Sirolimus for Patients With Recurrent or Refractory Sarcomas Including Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Phase I all unresectable soft tissue or bone sarcomas and Phase II unresectable malignant peripheral nerve sheath tumor (MPNST)
Drug: Ganetespib and Sirolimus
Accrual Status: Completed
SARC016
Phase 2 Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Malignant Peripheral Nerve Sheath Tumor (MPNST) either Sporadic or NF1 Associated
Drug: Bevacizumab and Everolimus
Accrual Status: Completed
SARC012
A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung
Type of Sarcoma: Osteosarcoma
Drug: Saracatinib and Placebo
Accrual Status: Completed