SARC023
A Phase I/II Trial of Ganetespib in Combination With the mTOR Inhibitor Sirolimus for Patients With Recurrent or Refractory Sarcomas Including Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Phase I all unresectable soft tissue or bone sarcomas and Phase II unresectable malignant peripheral nerve sheath tumor (MPNST)
Drug: Ganetespib and Sirolimus
Accrual Status: Completed
SARC022
A Phase 2 Study of Linsitinib (OSI-906) in Pediatric and Adult Wild Type Gastrointestinal Stromal Tumors
Type of Sarcoma: Gastrointestinal stromal tumors
Drug: OSI-906
Accrual Status: Completed
SARC021
A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination With Doxorubicin vs. Doxorubicin Alone in Subjects With Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma
Type of Sarcoma: Locally advanced or metastatic soft tissue sarcoma
Drug: TH-302 combined with doxorubicin vs. doxorubicin alone
Accrual Status: Completed
SARC020
Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma
Type of Sarcoma: Advanced or Metastatic Untreated Soft Tissue Sarcoma
Drug: Trabectedin Infused to Doxorubicin
Accrual Status: Terminated
SARC019
Study of Dose Escalation Versus no Dose Escalation of Imatinib in Metastatic Gastrointestinal Stromal Tumors (GIST) Patients
Type of Sarcoma: Metastatic GIST
Drug: Imatinib
Accrual Status: Terminated
SARC018 - SPORE01
SARC018: A Study of Mocetinostat and Gemcitabine in Patients With Metastatic Leiomyosarcoma
Type of Sarcoma: Metastatic Leiomyosarcoma
Drug: Mocetinostat & Gemcitabine
Accrual Status: Completed
SARC016
Phase 2 Study of the mTOR Inhibitor Everolimus in Combination With Bevacizumab in Patients With Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Malignant Peripheral Nerve Sheath Tumor (MPNST) either Sporadic or NF1 Associated
Drug: Bevacizumab and Everolimus
Accrual Status: Completed
SARC012
A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung
Type of Sarcoma: Osteosarcoma
Drug: Saracatinib and Placebo
Accrual Status: Completed
SARC011
A Study of R1507 in Participants With Recurrent or Refractory Sarcoma
Type of Sarcoma: Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma
Drug: R1507
Accrual Status: Completed
SARC009
Trial of Dasatinib in Advanced Sarcomas
Type of Sarcoma: Leiomyosarcoma, liposarcoma, MFH/pleomorphic undifferentiated sarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor, osteosarcoma (skeletal or extraosseous), chondrosarcoma, ewing’s, alveolar soft part sarcoma, chordoma, epithelioid sarcoma, giant cell tumor of bone, hemangiopericytoma/solitary fibrous tumor, gastrointestinal stromal tumors (GIST)
Drug: Dasatinib
Accrual Status: Completed
SARC007
A Trial of Perifosine in Patients With Chemo-Insensitive Sarcomas
Type of Sarcoma: Chondrosarcoma, extra-skeletal myxoid chondrosarcoma or alveolar soft part sarcoma
Drug: Perifosine
Accrual Status: Completed
SARC006
Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
Type of Sarcoma: Malignant peripheral nerve sheath tumors sporadic or NF1 associated
Drug: Adriamycin/ifosfamide and Adriamycin/etoposide
Accrual Status: Completed
SARC005
Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcoma
Type of Sarcoma: Uterine Leiomyosarcoma
Drug: Gemcitabine and Docetaxel
Accrual Status: Completed
SARC004
Neoadjuvant Imatinib in Dermatofibrosarcoma Protuberans
Type of Sarcoma: Dermatofirbrosarcoma Protuberans
Drug: Gleevec (Imatinib Mesylate)
Accrual Status: Completed
SARC003
Gemcitabine and Docetaxel in Treating Patients With Recurrent Osteosarcoma (Closed to Accrual as of 12/21/06) or Ewing's Sarcoma or Unresectable or Locally Recurrent Chondrosarcoma
Type of Sarcoma: Recurrent Ewing’s Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma
Drug: Gemcitabine and Docetaxel
Accrual Status: Completed