Publications

Year

Trial

Title / pubmed.gov

Journal

Sarcoma Subtype

First Author

2021

SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma

Cancer

Ewing Sarcoma

Chugh

2020

SARC021

Subgroup analysis of older patients treated within the randomized phase 3 doxorubicin versus doxorubicin plus evofosfamide (SARC021) trial

Journal of Geriatric Oncology

Locally advanced or metastatic soft tissue sarcoma

Younger

2020

SARC024

A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study

The Oncologist

Refractory Liposarcoma

Riedel

2020

SARC028

Correlative Analyses of the SARC028 Trial Reveal an Association Between Sarcoma-Associated Immune Infiltrate and Response to Pembrolizumab

Clinical Cancer Research

Undifferentiated Pleomorphic Sarcoma and Poorly Differentiated/
Dedifferentiated Liposarcoma

Keung

2020

SARC028

B cells are associated with survival and immunotherapy response in sarcoma

Nature

Undifferentiated Pleomorphic Sarcoma and Poorly Differentiated/
Dedifferentiated Liposarcoma

Petitprez

2019

SARC018

SARC018_SPORE02: Phase II Study of Mocetinostat Administered with Gemcitabine for Patients with Metastatic Leiomyosarcoma with Progression or Relapse following Prior Treatment with Gemcitabine-Containing Therapy

Sarcoma

Metastatic Leiomyosarcoma

Choy

2019

SARC024

Randomized Double-Blind Phase II Study of Regorafenib in Patients With Metastatic Osteosarcoma

Journal of Clinical Oncology

Osteogenic Sarcoma

Davis

2018

SARC009

Association of Dasatinib With Progression-Free Survival Among Patients With Advanced Gastrointestinal Stromal Tumors Resistant to Imatinib

JAMA Oncology

Advanced Gastrointestinal Stromal Tumors

Schuetze

2018

SARC018

Sarcoma

Metastatic Leiomyosarcoma

Choy

2017

SARC006

SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naïve Malignant Peripheral Nerve Sheath Tumors

Sarcoma

Malignant peripheral nerve sheath tumors sporadic or NF1 associated

Higham

2017

SARC009

Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor

Cancer

Alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor

Schuetze

2017

SARC021

Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial

The Lancet, Oncology

Locally advanced or metastatic soft tissue sarcoma

Tap

2017

SARC028

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

The Lancet, Oncology

Undifferentiated Pleomorphic Sarcoma and Poorly Differentiated/
Dedifferentiated Liposarcoma

Tawbi

2016

SARC009

SARC009: Phase 2 Study of Dasatinib in Patients With Previously Treated, High-Grade, Advanced Sarcoma

Cancer

Leiomyosarcoma, liposarcoma, MFH/pleomorphic undifferentiated sarcoma, rhabdomyosarcoma, malignant peripheral nerve sheath tumor, osteosarcoma (skeletal or extraosseous), chondrosarcoma, ewing’s, alveolar soft part sarcoma, chordoma, epithelioid sarcoma, giant cell tumor of bone, hemangiopericytoma/
solitary fibrous tumor, gastrointestinal stromal tumors (GIST)

Schuetze

2016

SARC011

Assessment of Imaging Modalities and Response Metrics in Ewing Sarcoma: Correlation With Survival

Journal of Clinical Oncology

Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma

Koshkin

2014

SARC011

A Phase 2 Trial of R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor-1 Receptor (IGF-1R), in Patients With Recurrent or Refractory Rhabdomyosarcoma, Osteosarcoma, Synovial Sarcoma, and Other Soft Tissue Sarcomas

Cancer

Ewing’s sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma

Pappo

2013

SARC005

Adjuvant therapy for high-grade, uterus-limited leiomyosarcoma: results of a phase 2 trial (SARC005)

Cancer

Uterine Leiomyosarcoma

Hensley

2012

SARC003

Phase II Study of Sequential Gemcitabine Followed by Docetaxel for Recurrent Ewing Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma: Results of Sarcoma Alliance for Research Through Collaboration Study 003

The Oncologist

Recurrent Ewing’s Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma

Fox

2010

SARC001

Efficacy of Imatinib in Aggressive Fibromatosis: Results of a Phase II Multicenter Sarcoma Alliance for Research through Collaboration (SARC) Trial

Clinical Cancer Research

Desmoid tumors

Chugh

2009

SARC001

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

Journal of Clinical Oncology

Ewing’s Family (including PNET), OsteosarcomaSynovial Sarcoma, Leiomyosarcoma, Rhabdomyosarcoma (including alveolar, embryonal and pleomorphic), Liposarcoma (all variants), Malignant Fibrous Histiocytoma, Peripheral Nerve Sheath (including MPNST, neurofibrosarcom, schwannoma), Fibrosarcoma, Angiosarcoma (all variants), Desmoid Tumor, GI Stromal (c-kit negative only)

Chugh

2007

SARC002

Randomized Phase II Study of Gemcitabine and Docetaxel Compared With Gemcitabine Alone in Patients With Metastatic Soft Tissue Sarcomas: Results of Sarcoma Alliance for Research Through Collaboration Study 002

Journal of Clinical Oncology

Unresectable soft tissue sarcoma

Maki